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DIABETES CONTROL
Perhaps the most imminent breakthrough for
resveratrol will be for the treatment of
type 2 diabetes.
In January of 2008 Sirtris Pharmaceuticals
announced that its version of Resveratrol
"significantly" lowered glucose (in an oral
glucose tolerance test) in HUMANS with Type
2 diabetes. Doses of 2.5 or 5 grams were
administered orally once a day for 28 days.
The patients experienced "no serious adverse
events and no dose related adverse events" -
in other words, Resveratrol was well
tolerated by the patients.
This study is significant because it shows
that Resveratrol might well be used to treat
type 2 diabetes in the near future and that
it seems to be well tolerated by patients at
large doses (2.5 to 5 grams per day).
Smaller doses might have the same beneficial
effects as indicated by an October study
where the equivalent of 15 mg. of
Resveratrol effectively increased insulin
sensitivity in diabetic mice.......
In July 2007, Sirtris Pharmaceuticals
announced that its version of resveratrol
reduced glucose and improved insulin
sensitivity in multiple pre-clinical models
of Type 2 Diabetes.
The results of this Sirtris study were no
surprise however. In November 2007, a study
was released in the publication Cell that
indicated that resveratrol administered
orally to mice protected them from gaining
weight and developing diabetes. A lead
researcher of the study, Johan Auwerx, said
a study of men and women from Finland
revealed that resveratrol will likely
produce similar results in humans.
It is possible that resveratrol fights
diabetes in two ways; by reducing glucose
and improving insulin sensitivity and by
increasing animals' metabolisms (thereby
decreasing weight gain - a main contributor
of type 2 diabetes). See 'Weight Loss' page.
Sirtis is currently performing a Phase 1b
resveratrol study in human patients with
Type 2 Diabetes. The results of this study
will be released in the second half of 2007.
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